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Emory School of Medicine Emory Woman's Mental Health Program
Antidepressants During Pregnancy and Breastfeeding - Postpartum Depression - Fluoxetine in Nursing
Zachary N. Stowe, M.D.

A Mother's Secret
Vogue Magazine, September 2001
Martha McPhee

At birth, placed on my belly, Livia turned her face to mine and gripped my eyes with her own - wise, fierce eyes, big and blue. She staked her claim to me, let me know unequivocally that I belonged to her. Those eyes swallowed me whole, terrifying me, as if she knew much more about how this rel ...View Full Article  


A New Rx for Healthier Pregnancies
By Marilyn Kennedy Melia Special to the Tribune January 21, 2004 If they belly up to a bar or light up in public, pregnant women are likely to face icy stares--or outright condemnation--from strangers. But those well-intentioned observers might want to hold their ire if they see a pregnant woman twisting off a medicine bottle cap and gulping d ...View Full Article  


Neurotensin-Dopamine Interactions: Relevance to Schizophrenia and the Action of Antipsychotic Drugs
Stowe, Z.N., Bissette, G., and Nemeroff, C.B. (1991) "Neurotensin-Dopamine Interactions: Relevance to Schizophrenia and the Action of Antipsychotic Drugs". Japanese Journal of Neuropsychopharmacology. 11(1): 49-59.


Sertraline in the Treatment of Women with Postpartum Onset Major Depression
Stowe Z.N., Casarella J., Landry J.C., and Nemeroff C.B. (1995) "Sertraline in the Treatment of Women with Postpartum Onset Major Depression". Depression. 3:49-55.


Women at Risk for Postpartum Depression
Stowe Z.N., and Nemeroff C.B. (1995) "Women at Risk for Postpartum Depression". American Journal of Obstetrics and Gynecology. 173:639-645.


Diagnosis and Treatment of Postpartum Depression
Winn S.S., Stowe Z.N., and Nemeroff C.B. "Diagnosis and Treatment of Postpartum Depression". Clinical Advances in the Treatment of Psychiatric Disorders. 10:1-11(Jan/Feb 1996).


Psychobiology of Postpartum Disorders
Wisner K.L. and Stowe Z.N. (1997) "Psychobiology of Postpartum Disorders". Seminars in Reproductive Endocrinology 15(1):77-89.


Sertraline and Desmethylsertraline in Human Breast Milk and Nursing Infants
Stowe Z.N., Owens M.J., Landry J.C., Kilts C., Ely T., Llewellyn A., and Nemeroff C.B. (1997) "Sertraline and Desmethylsertraline in Human Breast Milk and Nursing Infants". American Journal of Psychiatry. 154:1255-1260.


Depression During Pregnancy and the Puerperium
Llewellyn A., Stowe Z.N., and Nemeroff C.B. (1997) "Depression During Pregnancy and the Puerperium". Journal of Clinical Psychiatry. 58 [suppl. 15]:26-32.


Evaluation of Mental Health and Depression During Pregnancy: Position Paper
Hendrick V., Althsuler L., Cohen L.S., and Stowe Z.N. (1998) "Evaluation of Mental Health and Depression during Pregnancy: Position Paper". Psychopharmacology Bulletin. 34:297-299.


Depression in Women: Recognition and Treatment
Stowe Z.N. and Newport D.J. (1998) "Depression in Women: Recognition and Treatment". Women's Health in Primary Care. 1,10:29-39.


The Use of Lithium and Management of Women with Bipolar Disorder During Pregnancy and Lactation
Llewellyn A., Stowe Z.N., and Nemeroff C.B. (1998) "The Use of Lithium and Management of Women with Bipolar Disorder During Pregnancy and Lactation". Journal of Clinical Psychiatry. 59 [suppl 6]:57-64.


Depression in the Childbearing Years: Forum on Diagnostic in the OB/Gyn Setting
Sichel D.A., Burt V.K., Ciotti M.C, Ling F.W., and Stowe Z.N. (1999) "Depression in the Childbearing Years: Forum on Diagnostic in the OB/Gyn Setting". The Female Patient. 24: 69-82.


Treatment Issues During Pregnancy and Lactation
Baugh C.L. and Stowe Z.N. (1999) "Treatment Issues During Pregnancy & Lactation" CNS Spectrums. 4 (10): 34-39.


Serum Concentrations of Antidepressants and Benzodiazepines in Nursing Infants: Implications for Treatment
Birnbaum C.S., Cohen L.S., Grush L.R., Bailey J.W., Robertson L.M., and Stowe Z.N. (1999) "Serum Concentrations of Antidepressants and Benzodiazepines in Nursing Infants: Implications for Treatment". Pediatrics. (Electronic) 140(1):1-6.


Amniotic Fluid and Umbilical Cord Concentrations of Antidepressants in Three Women
Hostetter A., Ritchie J.C., and Stowe Z.N. (2000) "Amniotic Fluid and Umbilical Cord Concentrations of Antidepressants in Three Women". Biological Psychiatry 48:1032-1043.


Paroxetine in Breast Milk and Nursing Infants
Stowe Z.N., Cohen L.S., Hostetter A, Ritchie J.C., Owens M.J., and Nemeroff C.B. (2000) "Paroxetine in Breast Milk and Nursing Infants". American Journal of Psychiatry. 157:185-189.


Paroxetine Use During Breast -Feeding
Hendrick V., Stowe Z.N., Altshuler L.L., Hostetter A., and Fukuchi A. (2000) "Paroxetine Use During Breast- Feeding". Journal of Clinical Psychopharmacology. 20:287-288.


The Dose of Selective Serotonin Uptake Inhibitors Across Pregnancy: Clinical Implications
Hostetter A., Stowe Z.N., McLaughlin, E., Strader, J.R., and Llewellyn, A. M. (2000) "The Dose of Selective Serotonin Uptake Inhibitors Across Pregnancy: Clinical Implications". Depression and Anxiety. 11:51-57.


Antidepressants During Pregnancy and Lactation: Defining Exposure
Newport D.J., Wilcox M., and Stowe Z.N. (2001) "Antidepressants During Pregnancy and Lactation: Defining Exposure". Seminars in Perinatology. 25: 177-190.


The Course and Treatment of Mood Disorders in Women During Pregnancy and Lactation
Stowe Z.N., Calhoun K., Ramsey C., Sadek N., and Newport D.J. (2001) "The Course and Treatment of Mood Disorders in Women during Pregnancy and Lactation". CNS Spectrums. 6: 150-166.


Fluoxetine in Nursing Infants and Breast Milk
Hendrick, V., Stowe Z.N., Altshuler, L., Mintz, J., Hwang, S., Suri, R., Hostetter, A., Leight, K., Fukuchi, A. (2001) "Fluoxetine in Nursing Infants and Breast Milk". Biological Psychiatry. 50 (10): 775-782.


The Use of Psychotropic Medication During Lactation
Burt V., Hendrick V., Altshuler L., Stowe Z.N. (2001) "The Use of Psychotropic Medication during Lactation". The American Journal of Psychiatry. 158: 1001-1009.


Psychiatric Aspects of Postpartum Period
Arnold A. F., Baugh, C., Fisher, A., Brown, J., and Stowe, Z.N. (2002) "Psychiatric Aspects of Postpartum Period". Women's Mental Health, A Comprehensive Textbook. Kornstein Eds. New York, New York: The Guilford Press. pp. 91-113.


Maternal Depression: A Child's First Adverse Life Event
Newport DJ, Wilcox MM, Stowe ZN. (2002) Maternal depression: a child's first adverse life event. Seminars in Clinical Neuropsychiatry. 7(2): 113-119.


Estimates of Nursing Infant Daily Dose of Fluoxetine Through Breast Milk
Suri, R., Stowe, Z.N., Hendrick, V., Altshuler, L. (2002) Estimates of Nursing Infant Daily Dose of Fluoxetine through Breast Milk. Biological Psychiatry. 52, 446-451.


The Treatment of Postpartum Depression: Minimizing Infant Exposures
Newport DJ, Hostetter A, Arnold A, Stowe ZN. (2002) �The treatment of postpartum depression: minimizing infant exposures�. Journal of Clinical Psychiatry. 63(Supplement 7): 31-44.


Parental Depression: Animal Models of an Adverse Life Event
Newport DJ, Stowe ZN, Nemeroff CB. (2002) Parental depression: animal models of an adverse life event. American Journal of Psychiatry. 159(8): 1265-1283.


Depression
Stowe, Z.N. & Newport, D.J. Depression. In Zieman, M., Nelson, A.L., Wenger, N.K., King, J., James, C. eds. A Pocket Guide to Managing Menopause & More: 2003-2004 Edition.


The Pharmacokinetics of Sertraline Excretion into Human Breast Milk: Determinants of Infant Serum Concentrations
Stowe ZN, Hostetter AL, Owens MJ, Ritchie JC, Sternberg K, Cohen LS and Nemeroff CB. (2003) �The Phamacokinetics of Sertraline Excretion into Human Breast Milk: Determinants of Infant Serum Concentrations�. J Clinical Psychiatry. 64(1):73-80.


Placental Passage of Antidepressant Medications
Hendrick V, Stowe ZN, Altshuler LL, Hwang S, Lee E, Haynes D. (2003) �Placental Passage of Antidepressant Medications�. American Journal of Psychiatry 2003; 160:5, 993-996.


Antidepressants in Breast Milk: A Simple Method for Analysis
Hostetter, A., Ritchie J.C., and Stowe, Z.N. (2004) Antidepressants in Breast Milk: A Simple Method for Analysis. Therapuetic Drug Monitoring. 26(1):47-52.


Reintroduction of Antidepressant Across Pregnancy in Women Who Previously Discontinued Treatment
Cohen, L.S., Altshuler, L.L., Stowe, Z.N., Faroane, S.V. (2004) �Reintroduction of Antidepressant Across Pregnancy in Women Who Previously Discontinued Treatment�. Psychother Psychsom. 73(4): 255-258.


Management of Bipolar Disorder During Pregnancy and the Postpartum Period
Yonkers K.A,, Wisner K., Stowe Z.N., Leibenluft E., Cohen L., Miller L., Manber R., Viguera A., Suppes T., and Altshuler L. (2004) Management of Bipolar Disorder during Pregnancy and the Postpartum Period. American Journal of Psychiatry.161:608-620.


Management of Treatment Refractory Depression During Pregnancy and Postpartum Period
Stowe ZN, McCreary P, Hostetter A, Baugh C & Llewellyn A. "Management of Treatment Refractory Depression during Pregnancy & Postpartum Period". Treatment-resistant Mood Disorders. Amsterdam, Nierenberg & Hornig, eds. CambridgeUniv.


Timing of Symptom Onset in Postpartum Women Presenting with Depression
Stowe, Z.N., Hostetter, A., Newport, D.J. (2005) �Timing of Symptom Onset in Postpartum Women Presenting with Depression�. American Journal of Obstetrics & Gynecology. Feb; 192(2):522-6.


Placental Passage of Tricyclic Antidepressants
Loughhead A., Stowe Z.N., Newport D.J., Ritchie J.C., DeVane C.L., and Owens M.J. (2006) �Placental Passage of Tricyclic Antidepressants�. Biological Psychiatry Feb 1; 59 (3):287-90. Epub 2005 Nov 2 Epub.


Relapse of Major Depression During Pregnancy in Women Who Maintain or Discontinue Antidepressant Treatment
Cohen LS, Altshuler LL, Harlow BL, Nonacs R, Newport DJ, Viguera AC, Suri R, Burt VK, Hendrick V, Reminick AM, Loughhead A, Vitonis AF & Stowe ZN. (2006) �Relapse of major depression during pregnancy in women who maintain or discontinue antidepressant treatment.� JAMA. Feb 1;295(5):499-507.



Therapeutic Drug Monitoring of Psychoactive Drugs During Pregnancy in the Genomic Era: Challenges and Opportunities.
Devane CL. Stowe ZN. Donovan JL. Newport DJ. Pennell PB. Ritchie JC. Owens MJ. Wang JS. (2006) �Therapeutic drug monitoring of psychoactive drugs during pregnancy in the genomic era: challenges & opportunities�. J of Psychopharm. 20(4 Suppl):54-9l.


D. Jeffrey Newport, M.D., M.DIV.

Mood and Psychotic Disorders in Women: An Update on Treatment, Part 2
Newport DJ. (1999) Mood and psychotic disorders in women: an update on treatment, part 2. Resident & Staff Physician. (Special supplement): 24-26


Mood Disorders During Pregnancy and Lactation...
Stowe ZN, Calhoun K, Ramsey C, Sadek N, Newport DJ. (2001) Mood disorders during pregnancy and lactation: defining issues of exposure and treatment. CNS Spectrums. 6(2): 150-166.


Antidepressants During Pregnancy and Lactation: Defining Exposure and Treatment Issues
Newport DJ, Wilcox MM, Stowe ZN. (2001) Antidepressants during pregnancy and lactation: defining exposure and treatment issues. Seminars in Perinatology. 25(3): 177-190.


Maternal Depression: A Child's First Adverse Life Event
Newport DJ, Wilcox MM, Stowe ZN. (2002) Maternal depression: a child's first adverse life event. Seminars in Clinical Neuropsychiatry. 7(2): 113-119.


Maternal Depression in the Postpartum Period: Impact of Breast Feeding on
Treatment Planning Stowe ZN, Ragan K, Newport DJ. (2005) Maternal depression in the postpartum period: impact of breast feeding on treatment planning. In Riecher-Rossler A, Steiner M, eds. Bibl Psychiatr No.173, Perinatal Stress, Mood & Anxiety Disorders: From Bench to Bedside. Basel: Karger. pp 137-149


Parental Depression: Animal Models of and Adverse Life Event
Newport DJ, Stowe ZN, Nemeroff CB. (2002) Parental depression: animal models of an adverse life event. American Journal of Psychiatry. 159(8): 1265-1283.


Clinical Management of Perinatal Depression: Focus on Paroxetine
Newport, D.J. & Stowe, Z.N. (2003). Clinical Management of Perinatal Depression: Focus on Paroxetine. Psychopharmacology Bulletin, 37(Suppl 1), 148-166.


The Fetus and Maternal Depression: Implications for Antenatal
Treatment Guidelines Henry AL, Beach AJ, Stowe ZN, Newport DJ. (2004) The fetus & maternal depression: implications for antenatal treatment guidelines. Clin Obstet Gynecol. 47(3): 535-546


Psychiatric Disorders in Pregnancy
Levey L, Ragan K, Hower-Hartley A, Newport DJ, Stowe ZN. (2004) Psychiatric disorders in pregnancy. Neurol Clin. 22(4): 863-893


Guidelines for the Treatment of Schizophrenia During Pregnancy and the Postpartum Period
Stowe ZN, Newport DJ. Guidelines for the treatment of schizophrenia during pregnancy and the postpartum period. (2004) In IPAP Schizophrenia Algorithm Project. International Psychopharmacology Algorithm Project. pp 1-3, www.ipap.org/schiz


Alterations in Platelet Serotonin Transporter Binding in Women with Postpartum Onset Major Depression
Newport DJ, Owens MJ, Knight DL, Ragan KA, Morgan N, Nemeroff CB and Stowe ZN. (2004) Alterations in Platelet Serotonin Transporter Binding in Women with Postpartum Onset Major Depression. J Psychiatr Res 38: 467-473.


Lithium Placental Passage and Obstetrical Outcome: Implications for Clinical Management during Late Pregnancy
Newport DJ, Viguera AC, Beach AJ, Ritchie JC, Cohen LS & Stowe ZN. (2005) Lithium Placental Passage & Obstetrical Outcome: Implications for Clinical Management during Late Pregnancy. American Journal of Psychiatry. 162 (11):2162-2170.


The Onset of Postpartum Depression: Implications for Identification in Obstetrical and Primary Care
Stowe ZN, Hostetter A, Newport DJ. (2005) The onset of postpartum depression: implications for identification in obstetrical and primary care. Am J Obstet Gynecol. 192: 522-526


Venlafaxine in the Treatment of Depressive and Vasomotor Symptoms in Women With Perimenopausal Depression
Ladd CO, Newport DJ, Ragan KA, Loughhead A, Stowe ZN. (2005) Venlafaxine in the treatment of depressive and vasomotor symptoms in women with perimenopausal depression. Depress Anx. 22(2): 94-97


Maternal Depression: An Adverse Early Environment
Beach AJ, Henry AL, Stowe ZN, Newport DJ. (2005) Maternal depression: an adverse early environment. In Riecher-Rossler A, Steiner M, eds. Bibl Psychiatr No.173, Perinatal Stress, Mood & Anxiety Disorders: From Bench to Bedside. Basel: Karger. pp 70-84


Posttraumatic Stress Disorder in Pregnancy and the Postpartum Period
Stowe ZN, Newport DJ. (2005) Posttraumatic stress disorder in pregnancy and the postpartum period. In IPAP Post-Traumatic Stress Disorder Algorithm Notes. International Psychopharmacology Algorithm Project. pp 8-9, www.ipap.org/ptsd/


The Use of Antidepressants and Mood Stabilizers in Breast Feeding Women
Ragan K, Stowe ZN, Newport DJ. (2005) The use of antidepressants and mood stabilizers in breast feeding women. In Cohen LS, Nonacs RM, eds. Mood and Anxiety Disorders during Pregnancy and Postpartum. Washington DC: American Psychiatric Publishing, Inc. pp. 105-144


The Neural Correlates of Social Anxiety Disorder and Response to Pharmacotherapy
Kilts CD, Kelsey JE, Knight B, Ely TD, Bowman FD, Gross RE, Selvig A, Gordon A, Newport DJ, Nemeroff CB. (2006) The neural correlates of social anxiety disorder and response to pharmacotherapy. Neuropsychopharmacology. 31: 2243-2253


Therapeutic Drug Monitoring of Psychoactive Drugs During Pregnancy in the Genomic Era: Challenges and Opportunities
DeVane CL, Stowe ZN, Donovan JL, Newport DJ, Pennell PB, Ritchie JC, Owens MJ, Wang JS. (2006) Therapeutic drug monitoring of psychoactive drugs during pregnancy in the genomic era: challenges & opportunities. J Psychopharmacol. 20: 54-59


Using Antidepressants During Pregnancy: An Update
King E, Stowe ZN, Newport DJ. (2006) Using antidepressants during pregnancy: an update. Psychiatr Times. 23(9): 90-95


Mood Disorders in Women
Somerset W, Newport DJ, Ragan K, Stowe ZN. (2006) Mood disorders in women. In Keyes C, Goodman SH, eds. Women and Depression: A Handbook for the Social, Behavioral, and Biomedical Sciences. pp 62-88


Antidepressants in Amniotic Fluid: Another Route of Fetal Exposure
Loughhead AM, Fisher A, Newport DJ, Ritchie JC, Owens MJ and DeVane CL. (2006) Antidepressants in Amniotic Fluid: Another Route of Fetal Exposure. American Journal of Psychiatry. 163(1):145-147.


Psychopharmacology During Pregnancy and Lactation
Newport DJ, Stowe ZN. Psychopharmacology during pregnancy and lactation. In Schatzberg A, Nemeroff CB, eds. (2006) Essentials of Clinical Psychopharmacology, Second Edition. Washington DC: American Psychiatric Publishing, Inc. pp 745-77


Lithium in Breast Milk and Nursing Infants: Clinical Implications
Viguera AC. Newport DJ. Ritchie J. Stowe Z. Whitfield T. Mogielnicki J. Baldessarini RJ. Zurick A. Cohen LS. (February, 2007) Lithium in breast milk and nursing infants: clinical implications. American Journal of Psychiatry. 164(2):342-5, 2007.


Pancytopenia Associated With the Introduction of Oxcarbazepine
Calamaras MR. Stowe ZN. Newport DJ. (April, 2007) Pancytopenia associated with the introduction of oxcarbazepine. Journal of Clinical Psychopharmacology. 27(2):217-8.


Atypical Antipsychotic Administration During Late Pregnancy: Placental Passage and Obstetrical Outcomes
Newport DJ. Calamaras MR. DeVane CL. Donovan J. Beach AJ. Winn S. Knight BT. Gibson BB. Viguera AC. Owens MJ. Nemeroff CB. Stowe ZN. (August, 2007) Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes. American Journal of Psychiatry. 164(8):1214-20.


Page B. Pennell, M.D.

Focal Cerebral Magnetic Resonance Changes Associated with Partial Status Epilepticus
Henry TR, Drury I, Brunberg JA, Pennell PB, McKeever PE, Beydoun A. Focal cerebral magnetic resonance changes associated with partial status epilepticus. Epilepsia 1994; 35(1): 35-41.


Measurement of Synaptic Neurochemical Markers with Positron Emission Tomography
Pennell PB, Frey KA. (1994) Measurement of synaptic neurochemical markers with positron emission tomography. NeuroProtocols. 5: 42-53.


Aplastic Anemia in a Patient Receiving Felbamate for Complex Partial Seizures
Pennell PB, Ogaily MS, Macdonald RL. (1995) Aplastic anemia in a patient receiving felbamate for complex partial seizures. Neurology. 45: 456-460.


Temporal Lobe Central Benzodiazepine Binding in Unilateral Mesial Temporal Lobe Epilepsy
Burdette DE, Sakurai SY, Henry TR, Ross DA, Pennell PB, Frey KA, Sackellares JC, Albin RL (1995) Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy. Neurology. 45: 934-941.


Ictal Patterns in Temporal Lobe Epilepsy Recorded by Epidural Screw Electrodes
Drury I, Schuh L, Ross D, Pennell P, Varma N, Henry T. (1997) Ictal patterns in temporal lobe epilepsy recorded by epidural screw electrodes. Electroencephalography and Clinical Neurophys. 102: 167-174.


Neuropharmacological Imaging in Epilepsy with PET and SPECT
Henry TR, Pennell PB. (1998) Neuropharmacological imaging in epilepsy with PET and SPECT. Q J Nucl Med. 42:199-210.


Medication Use During Pregnancy for Neurological Conditions
Gilmore J, Pennell PB, Stern BJ. (1998) Medication use during pregnancy for neurological conditions. Neurologic Clinics. 16:189-206.


Absence of Normal Activation of the Left Anterior Fusiform Gyrus During Naming in Left Temporal Lobe Epilepsy
Henry TR, Buchtel HA, Koeppe RA, Pennell PB, Kluin KJ, Minoshima S. (1998) Absence of normal activation of the left anterior fusiform gyrus during naming in left temporal lobe epilepsy. Neurology. 50: 787-790.


Brain Blood Flow Alteration Induced by Therapeutic Vagus Nerve Stimulation in Partial Epilepsy
Henry TR, Bakay RAE, Votaw JR, Pennell PB, Epstein CM, Faber TL, Grafton ST, Hoffman JM. (1998) Brain blood flow alterations induced by therapeutic vagus nerve stimulation in partial epilepsy: Acute effects at high and low levels of stimulation. Epilepsia. 39: 983-990.


Muscarinic Receptor Loss with Preservation of Cholinergic Terminals in Mesial Temporal Sclerosis
Pennell PB, Burdette DE, Ross DA, Henry TR, Albin RL, Sackellares JC, Frey KA. (1999) Muscarinic receptor loss with preservation of cholinergic terminals in mesial temporal sclerosis. Epilepsia. 40: 38-46.


Acute Blood Flow Changes and Efficacy of Vagus Nerve Stimulation in Partial Epilepsy
Henry TR, Votaw JR, Pennell PB, Epstein CM, Bakay RAE, Faber TL, Grafton ST, Hoffman JM. (1999) Acute blood flow changes and efficacy of vagus nerve stimulation in partial epilepsy. Neurology. 52(6):1166-73.


Cholinergic Neuroreceptor Mapping
Pennell PB. PET: Cholinergic neuroreceptor mapping. In: Henry TR, Duncan JS, Berkovic SF, eds. (2000) Advances in Neurology, volume 83: Functional Imaging in the Epilepsies. Lippincott Williams & Wilkins, Philadelphia. 157-163.


Epilepsy
Pennell PB. (2000), Epilepsy. In: Cohen WR, ed. Cherry and Merkatz�s Complications of Pregnancy, 5th edition. Lippincott Williams & Wilkins, Philadelphia. 487-496.


Repetitive Transcranial Magnetic Stimulation Does Not Replicate the Wada Test
Epstein CM, Woodard JL, Stringer AY, Bakay RAE, Henry TR, Pennell PB, Litt B. (2000) Repetitive transcranial magnetic stimulation does not replicate the Wada test. Neurology. 55:1025-1027.


Epileptic Seizures May Begin Hours in Advance of Clinical Onset: A Report of Five Patients
Litt B, Esteller R, Echauz J, D�Alessandro M, Shor R, Henry T, Pennell P, Epstein C, Bakay R, Dichter M, Vachtsevanos G. (2001) Epileptic seizures may begin hours in advance of clinical onset: a report of five patients. Neuron. 30:51-64.


Remission of Intractable Partial Epilepsy Following Implantation of Intracranial Electrodes
Katariwala, Bakay RAE, Pennell PB, Olson LD, Henry TR, Epstein CM. (2001) Remission of intractable partial epilepsy following implantation of intracranial electrodes. Neurology. 57:1505-1507.


Pregnancy in Women with Epilepsy: Maternal and Fetal Outcome
Pennell PB. (2002) Pregnancy in women with epilepsy: maternal and fetal outcome. Seminars in Neurology. 22:299-307.


The Importance of Monotherapy in Pregnancy and Epilepsy
Pennell PB. (2003) The importance of monotherapy in pregnancy and epilepsy. Neurology. 60 (suppl 4):S31-S38.


Antiepileptic Drug Pharmacokinetics During Pregnancy and Lactation
Pennell PB. (2003) Antiepileptic drug pharmacokinetics during pregnancy and lactation. Neurology. 61(Suppl 2):S35-S42.


The Impact of Pregnancy and Childbirth on the Metabolism of Lamotrigine
Pennell PB, Newport DJ, Stowe ZN, Helmers SX, Montgomery JQ, Henry TR, Epstein CM. (2004) The Impact of Pregnancy and Childbirth on the Metabolism of Lamotrigine. Neurology. 62(2):292-295.


The Role of Therapeutic Drug Monitoring in Patient Care
Pennell PB. (2004) The role of therapeutic drug monitoring in patient care. Advanced Studies in Medicine. 4(6A):S15-S22.


Long Range Temporal Correlations in Epileptogenic and Non-Epileptogenic Human Hippocampus
Parish LM, Worrell GA, Cranstoun SD, Stead SM, Pennell P, Litt B. (2004) Long range temporal correlations in epileptogenic and non-epileptogenic human hippocampus. Neuroscience. 125:1069-1076.


Frequency of Catamenial Seizure Exacerbation in Women With Localization-Related Epilepsy
Herzog AG, Harden CL, Liporace J, Pennell P, Schomer DL, Sperling M, Fowler K, Nikolov B, Shuman S, Newman M. (2004) Frequency of catamenial seizure exacerbation in women with localization-related epilepsy. Ann Neurol. 56(3):431-434.


Pregnancy in Women Who Have Epilepsy
Pennell PB. (2004) Pregnancy in women who have epilepsy. Neurol Clin. 22(4):799-820.


Using Current Evidence in Selecting Antiepileptic Drugs For Use During Pregnancy
Pennell PB. (2005) Using current evidence in selecting antiepileptic drugs for use during pregnancy. Epilepsy Currents. 5(2):45-51.


Is Breast Milk the Best For Babies of Mothers on Levetiracetam?
Pennell PB. (2006) Is breast milk the best for babies of mothers on levetiracetam? Epilepsy Currents. 6(1):22-24.


Persistent Auditory Hallucinations that are Unresponsive to Antipsychotic Drugs
Nicolson SE, Mayberg HS, Pennell PB, Nemeroff CB. (2006) Persistent auditory hallucinations that are unresponsive to antipsychotic drugs. Am J Psychiatry. 163(7):1153-1159.


In Utero Antiepileptic Drug Exposure: Fetal Death and Malformations
Meador KJ, Baker GA, Finnell RH, Kalayjian LA, Liporace JD, Loring DW, Mawer G, Pennell PB, Smith JC, Wolff MC. (2006) In utero antiepileptic drug exposure: Fetal death and malformations. Neurology. 67(3):407-412.


AES Annual Course: Evidence Used to Treat Women with Epilepsy
Pennell PB. (2006) AES Annual Course: Evidence Used to Treat Women with Epilepsy. Epilepsia. Oct;47 Suppl 1:46-53


Michael J. Owens, Ph.D.

Recent Advances in the Neurobiology of Neuropeptides: Focus on Corticotropin-Releasing Factor
Nemeroff CB and Owens MJ. (1986) �Recent advances in the neurobiology of neuropeptides: focus on corticotropin-releasing factor�. Biological Psychiatry. 1985. (Shagass et al., Eds.). Elsevier Publishing, Amsterdam, 103-105.


Preclinical and Clinical Studies with Corticotropin-Releasing Factor: Implications for Affective Disorders
Owens MJ and Nemeroff CB. (1988) �Preclinical and clinical studies with corticotropin-releasing factor: Implications for affective disorders�. Psychopharmacology Bulletin 24:355-359.


Reduced Corticotropin-Releasing Factor (CRF) Binding Sites in the Frontal Cortex of Suicides
Nemeroff CB, Owens MJ, Bissette G, Andorn AC and Stanley M. (1988) �Reduced corticotropin-releasing factor (CRF) binding sites in the frontal cortex of suicides�. Archives of General Psychiatry 45:577-579.


Acute Effects of Alprazolam and Adinazolam on the Concentrations of Corticotropin-Releasing Factor in the Rat Brain
Owens MJ, Bissette G and Nemeroff CB. (1989) �Acute effects of alprazolam and adinazolam on the concentrations of corticotropin-releasing factor in the rat brain�. Synapse 4:196-202.


Neurotransmitter Regulation of CRF Secretion In Vitro
Owens MJ and Nemeroff CB. (1989) �Neurotransmitter regulation of CRF secretion in vitro. Corticotropin-Releasing Factor: Basic and Clinical Studies of a Neuropeptide �(EB DeSouza and CB Nemeroff, Eds.). CRC Press, Inc., Boca Raton, FL, 107-114.


Corticotropin-Releasing Factor: Possible Involvement in the Pathogenesis of Affective Disorders
Bond PE, Owens MJ, Butler PD, Bissette G and Nemeroff CB. (1989) �Corticotropin-releasing factor: possible involvement in the pathogenesis of affective disorders�. Molecular Biology of Stress (O Zinder and S Bresnitz, Eds.). 67-76.


Ecological Toxicology and Human Health Effects of Heptachlor
Fendick EA, Mather-Mihaich E, Houck KA, St. Clair MB, Faust JB, Rockwell CH and Owens MJ. (1990) �Ecological toxicology and human health effects of heptachlor�. Rev. Environmental Contamination and Toxicology 111:61-142.


Corticotropin-Releasing Factor: Brain and Cerebrospinal Fluid Studies
Vargas MA, Owens MJ and Nemeroff CB. (1990) �Corticotropin-releasing factor: brain and cerebrospinal fluid studies�. CNS Peptide Mechanisms in Stress and Depression (SC Risch, Ed.), American Psychiatric Association Press, Washington, D.C., 73-9.


Corticotropin-Releasing Factor: Preclinical and Clinical Studies
Nemeroff CB, Bissette G, Owens MJ, Vargas MA, Pihoker C, Krishnan KRR, Cain ST and Banki CM. (1990) �Corticotropin-releasing factor: preclinical and clinical studies�. Clinical Neuropharmacology 13: (Suppl. 2-3) 595-596.


The Effects of 5-HT1A Agonists on HPA Axis Activity and CRF-Containing Neurons in the Rat Brain
Owens MJ, Edwards E and Nemeroff CB. (1990) �The effects of 5-HT1A agonists on HPA axis activity and CRF-containing neurons in the rat brain�. European J. Pharmacology 190:113-122.


Role for the Brain Corticotropin-Releasing Factor in the Weight Reducing Effects of Chronic Fenfluramine Treatment in Rats
Appel NM, Owens MJ, Culp C, Zaczek R, Contrera JF, Bissette G, Nemeroff CB and De Souza EB. (1991) �Role for brain corticotropin-releasing factor in the weight reducing effects of chronic fenfluramine treatment in rats�. Endocrinology 128:3237-3246.


Subcellular Distribution of Corticotropin-Releasing Factor in the Rat Central Nervous System
Cain ST, Owens MJ and Nemeroff CB. (1991) �Subcellular distribution of corticotropin-releasing factor in the rat central nervous system�. Neuroendocrinology 54:36-41.


Postnatal Development of Brain Corticotropin-Releasing Factor Receptors in the Rat
Pihoker C, Cain ST, Owens MJ and Nemeroff CB. (1991) �Postnatal development of brain corticotropin-releasing factor receptors in the rat�. Horizons in Endocrinology Volume II. Serono Symposia 76, (M Maggi and V Geenen, Eds.). Raven Press, NY.


The Physiology and Pharmacology of Corticotropin-Releasing Factor (CRF)
Owens MJ and Nemeroff CB. (1991) �The physiology and pharmacology of corticotropin-releasing factor (CRF)�. Pharmacological Reviews 43:430-471.


Preliminary Studies of 6b-hydroxydexamethasone & its Implications in the DST.
Ritchie JC, Owens MJ, Mayer H, Watson JT, Kilts CD and Nemeroff CB. (1992) �Preliminary studies of 6b-hydroxydexamethasone and its implications in the DST�. Biological Psychiatry 32:825-833


Corticotropin-Releasing Factor (CRF): Studies in Alcohol Preferring and Non-Preferring Rats
Ehlers CL, Chaplin RI, Wall TL, Lumeng L, Li TK, Owens MJ and Nemeroff CB. (1992) �Corticotropin-releasing factor (CRF): studies in alcohol preferring and non-preferring rats�. Psychopharmacology 106:359-364.


Effects of Chronic Ethanol and Benzodiazepine Treatment and Withdrawal on Corticotropin-Releasing Factor Neural Systems
Vargas MA, Bissette G, Owens MJ, Ehlers CL and Nemeroff CB. (1992) Effects of chronic ethanol and benzodiazepine treatment and withdrawal on corticotropin-releasing factor neural systems. Ann. New York Acad. Sci. 654:145-152.


5a-pregnane-3a, 21-diol-20-one (THDOC) Aattenuates Mild Stress-Induced Increases in Plasma Corticosterone via a Non-Glucocorticoid Mechanism: Comparison with Alprazolam
Owens MJ, Ritchie JC and Nemeroff CB. (1992) 5a-pregnane-3a, 21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism: comparison with alprazolam. Brain Research 573:353-355


Neuropeptides and Mental Illness: Focus on Affective Disorders
Bissette G, Owens MJ and Nemeroff CB. (1992) �Neuropeptides and mental illness: focus on affective disorders�. Biological Psychiatry, Volume 2 (G Raggani et al., Eds.). Elsevier, New York, 543-545.


Effects of Gender and Social Isolation on Electroencephalogram and Neuroendocrine Parameters in Rats
Ehlers CL, Kaneko WM, Owens MJ and Nemeroff CB. (1993) �Effects of gender and social isolation on electroencephalogram and neuroendocrine parameters in rats�. Biological Psychiatry 33:358-366.


The Role of CRF in the Pathophysiology of Affective Disorders: Laboratory and Clinical Studies
Owens MJ and Nemeroff CB. (1993) �The role of CRF in the pathophysiology of affective disorders: laboratory and clinical studies�. Ciba Foundation Symposium on Corticotropin-Releasing Factor 172, (WW Vale, Ed.), John Wiley & Sons, NY, 296-316.


Corticotropin-Releasing Factor in Depression
Hartley PR, Owens MJ and Nemeroff CB. (1993) �Corticotropin-releasing factor in depression�. Directions in Psychiatry. 13:1-8.


The BE(2)-M17 Neuroblastoma Cell Line Secretes Corticotropin-Releasing Factor and is Responsive to Forskolin
Kasckow JW, Parkes DG, Owens MJ, Stipetic MD, Han J-H, Nemeroff CB and Vale WW. (1994) �The BE (2)-M17 neuroblastoma cell line secretes corticotropin-releasing factor and is responsive to forskolin�. Brain Research 646:315-318.


The Effects of Alprazolam on Corticotropin-Releasing Factor Neurons in the Rat Brain: Implications for a Role for CRF in the Pathogenesis of Anxiety Disorders
Owens MJ, Vargas MA, Knight DL and Nemeroff CB. (1994) �The effects of alprazolam on corticotropin-releasing factor neurons in the rat brain: implications for a role for CRF in the pathogenesis of anxiety disorders�. J. Psychiatric Research 27(S1):2.


Corticotropin-Releasing Factor is Secreted in the BE(2)-C Neuroblastoma Cell and is Responsive to Forskolin
Kasckow JW, Owens MJ, Stipetic MD, Han J-H and Nemeroff CB. (1994) �Corticotropin-releasing factor is secreted in the BE (2)-C neuroblastoma cell and is responsive to forskolin�. Life Sciences 54:1825-1829.


The Role of Serotonin in the Pathophysiology of Depression: Focus on the Serotonin Transporter
Owens MJ and Nemeroff CB. (1994) �Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter�. Clinical Chemistry 40:288-295.


Pharmacological Characterization of the Putative Antidepressant Nefazodone
Owens MJ, Dole KC, Knight DL and Nemeroff CB. (1994) �Pharmacological characterization of the putative antidepressant nefazodone�. Depression 1:315-323.


Experimental Studies of Depression and Anxiety: Role of Locus Ceruleus and Corticotropin-Releasing Factor
Weiss JM, Stout JC, Aaron MF, Owens MJ and Nemeroff CB. (1994) �Experimental studies of depression and anxiety: role of locus ceruleus and corticotropin-releasing factor�. Brain Research Bulletin 35:561-572.


Interleukin-1a Induces Corticotropin-Releasing Factor Secretion and Synthesis from NPLC-KC Cells ThroughVarious Second Messenger Pathways
Kasckow JW, Mulchahey JJ, Han J, Owens MJ, Stipetic MD, Breitman D & Nemeroff CB. (1994) �Interleukin-1a induces corticotropin-releasing factor secretion & synthesis from NPLC-KC cells through various second messenger pathways�. Synapse 18:354-35


Exposure to Antisense Oligonucleotide Decreases CRF Receptor Binding in Rat Pituitary Cultures
Owens MJ, Mulchahey JJ, Kasckow JW, Plotsky PM and Nemeroff CB. (1995) �Exposure to an antisense oligonucleotide decreases CRF receptor binding in rat pituitary cultures�. J Neurochemistry 64:2358-2361.


Atypical Antipsychotics
Owens MJ and Risch SC. (1995) �Atypical antipsychotics�. In: Textbook of Psychopharmacology (AF Schatzberg and CB Nemeroff, Eds.), American Psychiatric Association Press, Washington, DC, pp. 263-280.


Chronic Haloperidol-Induced Changes in Regional Dopamine Release and Metabolism and Neurotensin Content in Rats
See RE, Lynch AM, Aravagiri M, Nemeroff CB and Owens MJ. (1995) �Chronic haloperidol-induced changes in regional dopamine release and metabolism and neurotensin content in rats�. Brain Research 704:202-209.


Ontogeny of the Effect of Antipsychotic Drug Treatment on Neurotensin Concentrations in the Rat Brain
Kinkead B, Owens MJ and Nemeroff CB. (1995) �Ontogeny of the effect of antipsychotic drug treatment on neurotensin concentrations in the rat brain�. Synapse 20:244-248.


The Serotonergic Antidepressant Nefazodone Inhibits the Serotonin Transporter: In Vivo and Ex Vivo Studies
Owens MJ, Ieni JR, Knight DL, Winders K & Nemeroff CB. (1995) �The serotonergic antidepressant nefazodone inhibits the serotonin transporter: in vivo & ex vivo studies�. Life Sciences 57:PL373-PL380.


Peptides and Affective Disorders
Owens MJ, Plotsky PM and Nemeroff CB. (1996) �Peptides and affective disorders�. Biology of Schizophrenia and Affective Disorders (SJ Watson, Ed.), American Psychiatric Press, Washington , DC, pp. 259-293.


Postmortem and Cerebrospinal Fluid Studies of CRF in Humans
Hartline KM, Owens MJ and Nemeroff CB. (1996) �Postmortem and cerebrospinal fluid studies of CRF in humans�. Ann. New York Acad. Sci. 780:96-105.


Molecular and Neurobiological Mechanisms in the Treatment of Psychiatric Disorders
Owens MJ, Mulchahey JJ and Plotsky PM. (1996) �Molecular and neurobiological mechanisms in the treatment of psychiatric disorders�. Psychiatry (A Tasman, J Kay and JA Lieberman, Eds.), WB Saunders Co., Philadelphia, pp. 210-257.


Persistent Changes in Corticotropin-Releasing Factor Systems Due to Early Life Stress: Relationship to the Pathophysiology of Major Depression and Post-Traumatic Stress Disorder
Heim C, Owens MJ, Plotsky PM and Nemeroff CB. (1997) �Persistent Changes in Corticotropin-Releasing Factor Systems Due to Early Life Stress: Relationship to the Pathophysiology of Major Depression and Post-Traumatic Stress Disorder�. Psychopharmacology Bulletin. 33(2):185-92.


Persistent Changes in Corticotropin-Releasing Factor Neuronal Systems Induced by Maternal Deprivation
Ladd CO, Owens MJ and Nemeroff CB. (1996) �Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation�. Endocrinology 137:1212-1218.


Elevated CSF Corticotropin-Releasing Factor Concentrations in Posttraumatic Stress Disorder
Bremner JD, Licinio J, Darnell A, Krystal JH, Owens MJ, Southwick SM, Nemeroff CB and Charney DS. (1997) �Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder�. American J. Psychiatry 154:624-629.


The Role of Early Adverse Life Events in the Etiology of Depression and Post-Traumatic Stress Disorder: Focus on Corticotropin-Releasing Factor.
Heim C, Owens MJ, Plotsky PM and Nemeroff CB. (1997) �The role of early adverse life events in the etiology of depression and post-traumatic stress disorder: focus on corticotropin-releasing factor�. Ann. New York Acad. Sci. 821:194-207.


Molecular and Cellular Mechanisms of Antidepressant Drugs
Owens MJ. (1997) �Molecular and cellular mechanisms of antidepressant drugs�. Depression and Anxiety 4:153-159.


Neuropeptides in Bipolar Disorder
Risby ED, Hartline K, Owens MJ and Nemeroff CB. (1997) �Neuropeptides in bipolar disorder�. Bipolar Disorder: Biological Models and Their Clinical Applications (LT Young and RT Joffe, Eds.), Marcel Dekker, Inc., New York, pp. 161-178.


Excretion of Sertraline in Human Breast Milk and Nursing Infants
Stowe ZN, Owens MJ, Landry JC, Kilts CD, Ely T, Llewellyn A and Nemeroff CB. (1997) Excretion of Sertraline in Human Breast Milk and Nursing Infants. American J. Psychiatry 154:1255-1260.



Heit S, Owens MJ, Plotsky PM and Nemeroff CB. (1997) Corticotropin-releasing factor, stress, and depression. The Neuroscientist 3:186-194.


Neurotransmitter Receptor and Transporter Binding Profile of Antidepressants and Their Metabolites
Owens MJ, Morgan WN, Plott S and Nemeroff CB. (1997) �Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites�. J. Pharmacology and Experimental Therapeutics 283:1305-1322.


Corticotropin-Releasing Factor (CRF), CRF-Binding Protein (CRF-BP) and CRF/CRF-BP Complex in Alzheimer's Disease and Normal Post-mortem Human Brain
Behan DP, Khongsaly O, Owens MJ, Nemeroff CB and De Souza EB. (1997) �Corticotropin releasing factor (CRF), CRF-binding protein (CRF-BP) and CRF/CRF-BP complex in Alzheimer�s disease and normal post-mortem human brain�. J. Neurochemistry. 68:2053-206.


Steroid-Independent Translocation of the Glucocorticoid Receptor Induced by the Antidepressant Desipramine
Pariante C, Pearce BD, Owens MJ and Miller AJ. (1997) Steroid-independent translocation of the glucocorticoid receptor induced by the antidepressant desipramine. Molecular Pharmacology 52:571-581.


Use of Psychotropic Medications During Lactation
Stowe ZN and Owens MJ. (1998) �Use of psychotropic medications during lactation�. American Journal of Psychiatry. 155:1626-1627.


Psychoneuroendocrinology of Depression: Hypothalamic-Pituitary-Adrenal Axis
Plotsky PM, Owens MJ and Nemeroff CB. (1998) �Psychoneuroendocrinology of depression: hypothalamic-pituitary-adrenal axis�. Psychiatric Clinics of North America 21:293-307.


The Serotonin Transporter and Depression
Owens MJ and Nemeroff CB. (1998) �The serotonin transporter and depression�. Depression and Anxiety 8(S1):5-12.


Atypical Antipsychotics
Owens MJ and Risch SC. (1998) �Atypical antipsychotics�. Textbook of Psychopharmacology (AF Schatzberg and CB Nemeroff, Eds.), 2nd edition, American Psychiatric Association Press, Washington, DC, pp 323-348.


Neurotensin Studies in Alcohol Naive, Preferring and Non-Preferring Rats
Ehlers CL, Somes C, Li TK, Lumeng L, Kinkead B, Owens MJ and Nemeroff CB. (1999) �Neurotensin studies in alcohol naive, preferring and non-preferring rats�. Neuroscience 93:227-236.


Corticotropin Releasing Factor Antagonists in Affective Disorders
Owens MJ and Nemeroff CB. (1999) �Corticotropin releasing factor antagonists in affective disorders�. Expert Opinions on Investigational Drugs 8:1849-1858.


Corticotropin-Releasing Factor Antagonists: Therapeutic Potential in the Treatment of Affective Disorders
Owens MJ and Nemeroff CB. (1999) �Corticotropin-releasing factor antagonists: therapeutic potential in the treatment of affective disorders�. CNS Drugs 12:85-92.


The Role of Corticotropin-Releasing Factor (CRF) in Depression and Anxiety Disorders
Arborelius L, Owens MJ, Plotsky PM and Nemeroff CB. (1999) �The role of corticotropin-releasing factor (CR) in depression & anxiety disorders�. J. Endocrinology 160:1-12.


Clinical Neurochemistry
Owens MJ and Ritchie JC. (1999) �Clinical neurochemistry�. Neurobiology of Mental Illness (DS Charney, EJ Nestler and BS Bunney, Eds.), Oxford University Press, New York, pp. 132-148.


Effects of Acute and Subchronic Administration of Typical and Atypical Antipsychotic Drugs on the Neurotensin System of the Rat Brain
Kinkead B, Owens MJ and Nemeroff CB. (2000) �Effects of acute and subchronic administration of typical and atypical antipsychotic drugs on the neurotensin system of the rat brain�. J. Pharmacology & Experimental Therapeutics 295:67-73.


Nefazodone
Garlow SJ, Owens MJ, Kelsey J and Nemeroff CB. (2000) �Nefazodone�. Comprehensive Textbook of Psychiatry/VII (BJ Sadock and VA Sadock, Eds.), Lippincott Williams and Wilkins, Baltimore, pp. 2412-2418.


Neuropeptides: Biology and Regulation
Owens MJ, Nemeroff CB and Bissette G. (2000) �Neuropeptides: biology & regulation�. Comprehensive Textbook of Psychiatry/VII (BJ Sadock and VA Sadock, Eds.), Lippincott Williams and Wilkins, Baltimore, pp. 60-70.


Corticotropin-Releasing Factor Antagonists as Novel Psychotherapeutics
Gutman DA, Owens MJ and Nemeroff CB. (2000) �Corticotropin-releasing factor antagonists as novel psychotherapeutics�. Drugs of the Future 25:923-931.


Chronic Administration of the Triazolobenzodiazepine Alprazolam: Bioavailability and Opposite Regulation of Corticotropin-Releasing Factor and Urocortin Systems
Skelton KH, Nemeroff CB, Knight DL and Owens MJ. (2000) �Chronic administration of the triazolobenzodiazepine alprazolam: bioavailability and opposite regulation of corticotropin-releasing factor and urocortin systems�. J. Neuroscience 20:1240-1248.


A Comparison of Plasma Alprazolam Concentrations Following Different Routes of Chronic Administration in the Sprague-Dawley Rat: Implications for Psychotropic Drug Research
Skelton KH, Nemeroff CB and Owens MJ. (2000) �A comparison of plasma alprazolam concentrations following different routes of chronic administration in the Sprague-Dawley rat: implications for psychotropic drug research�. Psychopharmacology 151:72-76.


Increased Corticotropin-Releasing Factor Concentrations in the Bed Nucleus of the Stria Terminalis of Anhedonic Rats
Stout SC, Mortas P, Owens MJ, Nemeroff CB and Moreau J-L. (2000) �Increased corticotropin-releasing factor concentrations in the bed nucleus of the stria terminalis of anhedonic rats�. European J. Pharmacology 401:39-46.


Paroxetine Binding to the Rat Norepinephrine Transporter In Vivo
Owens MJ, Knight DL and Nemeroff CB. (2000) �Paroxetine binding to the rat norepinephrine transporter in vivo�. Biological Psychiatry 47:842-845.


Paroxetine in Human Breast Milk and Nursing Infants
Stowe ZN, Cohen LS, Hostetter A, Ritchie JC, Owens MJ and Nemeroff CB. (2000) �Paroxetine in human breast milk and nursing infants�. American Journal of Psychiatry 157:185-189.


The Effects of Acute Antipsychotic Drug Administration on the Neurotensin System of the Developing Rat Brain
Kinkead B, Owens MJ and Nemeroff CB. (2000) �The effects of acute antipsychotic drug administration on the neurotensin system of the developing rat brain�. Brain Research Dev Brain Res 124:1-10.


Effects of Sodium Valproate on Corticotropin-Releasing Factor Systems in Rat Brain
Stout SC, Owens MJ, Lindsey KP, Knight DL and Nemeroff CB. (2001) �Effects of sodium valproate on corticotropin-releasing factor systems in rat brain�. Neuropsychopharmacology 24:624-631.


An Old Transmitter in a New Millenium
Owens MJ and Nemeroff CB. (2001) �An old transmitter in a new millennium�. CNS Spectrums 6:655.


Are CRF Receptor Antagonists Potential Antidepressants?
O�Brien D, Skelton KH, Owens MJ and Nemeroff CB. (2001) �Are CRF receptor antagonists potential antidepressants?� Human Psychopharmacology 16:81-87.


CRF Receptor Antagonists: A New Approach to the Treatment of Depression
Gutman DA, Owens MJ and Nemeroff CB. (2001) �CRF receptor antagonists: a new approach to the treatment of depression�. Pharmaceutical News 8:18-25.


Neurokinin1 Receptor Antagonists as Potential Antidepressants
Stout SC, Owens MJ and Nemeroff CB. (2001) �Neurokinin1 receptor antagonists as potential antidepressants�. Annual Reviews in Pharmacology & Toxicology 41:877-906.


Neurotensin and Dopamine Interactions
Binder E, Kinkead B, Owens MJ and Nemeroff CB. (2001) �Neurotensin and dopamine interactions�. Pharmacological Reviews 53:453-486.


The Role of Neurotensin in the Pathophysiology of Schizophrenia and the Mechanism of Action of Antipsychotic Drugs
Binder EB, Kinkead B, Owens MJ and Nemeroff CB. (2001) �The role of neurotensin in the pathophysiology of schizophrenia and the mechanism of action of antipsychotic drugs�. Biological Psychiatry 50:856-872.


Synthesis and Characterization of Fluorinated and Iodinated Pyrrolopyrimidines as PET/SPECT Ligants for the CRF1 Receptor
Martarello L, Kilts CD, Ely T, Owens MJ, Nemeroff CB, Camp M & Goodman MM. (2001) �Synthesis and characterization of fluorinated and iodinated pyrrolopyrimidines as PET/SPECT ligands for the CRF1 receptor�. Nuclear Medicine & Biology. 28:187-195.


The Effects of Glutamatergic Agonists on Neurotensin Release Using In Vivo Microdialysis
Radke JM, Owens MJ and Nemeroff CB. (2001) �The effects of glutamatergic agonists on neurotensin release using in vivo microdialysis�. Eur J Pharmacology 411:129-134.


Second Generation SSRIs: Human Monoamine Transporter Binding Profile of Escitalopram and R-Fluoxetine
Owens MJ, Knight BS and Nemeroff CB. (2001) �Second generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine�. Biological Psychiatry 50:345-350.


Inhibition of the Norepinephrine Transporter in Depressed Patients Treated with Paroxetine
Gilmor M, Owens MJ and Nemeroff CB. (2002) �Inhibition of the norepinephrine transporter in depressed patients treated with paroxetine�. American Journal of Psychiatry 159:1702-1710.


Treatment of Mood Disorders
Nemeroff CB and Owens MJ. (2002) �Treatment of mood disorders�. Nature Neuroscience 5(suppl):1068-1070.


Regulation of CRF Gene Expression and Peptide Concentrations by Stress and Chronic Antidepressant Treatment
Stout SC, Owens MJ and Nemeroff CB. (2002) �Regulation of CRF gene expression and peptide concentrations by stress and chronic antidepressant treatment�. J. Pharmacology & Experimental Therapeutics 300:1085-1092.


Escitalopram: A Second Generation SSRI
Owens MJ and Rosenbaum JF. (2002) �Escitalopram: a second generation SSRI�. CNS Spectrums 7(4S1):34-39, 2002.


Cellular and Behavioral Effects of D2 Dopamine Receptor Hydrophobic Eigenmode-Targeted Peptide Ligands
Mandell AJ, Selz KA, Owens MJ, Kinkead B, Shlesinger MF, Gutman DA and Arcuragi V. (2003) �Cellular and behavioral effects of D2 dopamine receptor hydrophobic eigenmode-targeted peptide ligands�. Neuropsychopharmacology 28:S98-S107.


Neuropharmacology of Paroxetine
Owens MJ and Nemeroff CB. (2003) �Neuropharmacology of paroxetine�. Psychopharmacology Bulletin 37(S1):8-18.


The Effects of Chronic Treatment with the Mood Stabilizers Valproic Acid and Lithium on Corticotropin-Releasing Factor Neuronal Systems
Gilmor ML, Skelton KH, Nemeroff CB and Owens MJ. (2003) �The effects of chronic treatment with the mood stabilizers valproic acid and lithium on corticotropin-releasing factor neuronal systems�. J. Pharmacology & Experimental Therapeutics 305:434-439.


Stereochemistry and Drug Action
McConathy J and Owens MJ. (2003. �Stereochemistry and drug action�. J. Clinical Psychiatry � Primary Care Companion 5:70-73.


The CRF1 Receptor Agonist, R121919, Blocks Endocrine and Behavioral Response to Stress
Gutman DG, Owens MJ and Nemeroff CB. (2003) �The CRF1 receptor antagonist, R121919, blocks endocrine and behavioral responses to stress�. J. Pharmacology & Experimental Therapeutics 304:874-880.


Clinical
Owens MJ and Ritchie JC. (2004) �Clinical neurochemistry�. Neurobiology of Mental Illness, 2nd edition (DS Charney, EJ Nestler and BS Bunney, Eds.), Oxford University Press, New York. pp. 141-154.


Milnacipran: A Comparative Analysis of Human Monoamine Uptake and Transporter Binding Affinity
Vaishnavi SN, Nemeroff CB, Plott SJ, Rao SG, Kranzler J and Owens MJ. (2004) Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biological Psychiatry 55:320-322.


Pharmacology of Valproate
Owens MJ and Nemeroff CB. (2004) �Pharmacology of Valproate�. Psychopharmacology Bulletin 37(S2):17-24.




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